ChemicalBook CAS DataBase List 1852-38-6

1852-38-6

Name	PREGNENOLONE SULFATE SODIUM SALT
CAS	1852-38-6
Molecular Formula	C21H31NaO5S
MDL Number	MFCD00056177
Molecular Weight	418.52
MOL File	1852-38-6.mol

Chemical Properties

Melting point	192 °C(lit.)
storage temp.	Store at -20°C
solubility	methanol and water: 1.93 mg/mL
form	A crystalline solid
color	White to off-white
InChIKey	ABFNHVDDMHKJKK-WRHGONFGSA-N
SMILES	[Na].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O)OS(O)(=O)=O

Safety Data

WGK Germany	3
Storage Class	11 - Combustible Solids

Hazard Information

Description

Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).

Uses

Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).

Uses

Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.

Biochem/physiol Actions

Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.

in vivo

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule^[1].

IC 50

CB1; Human Endogenous Metabolite

storage

Store at +4°C

References

[1] M SEDLáCEK. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.[J]. Physiological research, 2008, 57 Suppl 3: S49-S57. DOI: 10.33549/physiolres.931600
[2] CONOR C SMITH David H F Terrell T Gibbs. Pregnenolone sulfate as a modulator of synaptic plasticity.[J]. Psychopharmacology, 2014, 231 17: 3537-3556. DOI: 10.1007/s00213-014-3643-x
[3] GERALD THIEL Oliver G R Isabelle Müller. Signal transduction via TRPM3 channels in pancreatic β-cells.[J]. Journal of molecular endocrinology, 2013, 50 3: R75-83. DOI: 10.1530/jme-12-0237

Spectrum Detail

Supplier

J & K SCIENTIFIC LTD.

Telephone18210857532 18210857532

Websitehttps://www.jkchemical.com

Spectrum Chemical Manufacturing Corp.

Telephone021-021-021-67601398-809-809-809 15221380277

Websitehttps://www.spectrumchemical.com/OA_HTML/index.jsp?minisite=10020&respid=22372&language=US

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Jinan Yaoyan Pharmaceutical Co., Ltd.

Telephone

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30574/0_EN.htm

Shanghai Hongye Biotechnology Co. Ltd

Telephone400-9205774 400-920-5774

Websitehttp://www.glpbio.cn/

Beijing Minruida Technology Co., Ltd.

Telephone010-82387566

Websitehttp://www.mreda.com.cn/

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Telephone+86-400-002-6226

Websitehttps://www.rrkchem.com

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Telephonemeitaochem@126.com

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31244/0_EN.htm

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Telephone 18818260767

Websitehttp://www.chemegen.com

CHIRIAL CO.LTD

Telephone+86-025-58218501; 19941513806

Websitehttps://www.chirial.com

Energy Chemical

Telephone400-0056266

Websitehttp://www.energy-chemical.com

Qingdao Tenglong microwave technology co., LTD.

Telephone0532-83818797 17669478191

Websitehttp://www.cnnmr.com/

Manhag Testing Technology Co., Ltd

Telephone400-818 0104 18918165978

Websitehttp://www.bepurestandards.com/

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840

Websitehttp://www.jm-bio.com/

JinOu Biomedical (Nanjing) Co., Ltd.

Telephone 13000000000

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1596079/0_EN.htm

Yancheng Tongming Biotechnology Co., Ltd.

Telephone 15195160625

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1089086/0_EN.htm

1of4

Related Products

Send Inquriy