Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC50 value of 1.30 μM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue[1][2].
References
[1] Hansen DT, et al. The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Bioorg Med Chem Lett. 2024 May 15;104:129740. DOI:10.1016/j.bmcl.2024.129740 [2] Ling Q, et al. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg Med Chem. 2008 Aug 1;16(15):7399-409. DOI:10.1016/j.bmc.2008.06.014
