18471-20-0

Ageroplas,Serona,Italy,1973

Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation.

ChEBI: Ditazole is a member of 1,3-oxazoles.

A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The solvent was stripped at 1 mm and the oily residue was added at 60°C to 100 ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β- hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The product crystallized from ethyl ether + petroleum ether, with a MP of 96 to 98°C.

Antiinflammatory