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Aminooxy-PEG3-t-butyl ester is an aminooxy-containing PEG molecule. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy group is reactive with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The t-butyl ester can be converted tofree acid under acidic condition. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.