ChemicalBook CAS DataBase List 182959-33-7

182959-33-7

Name	YM-53601
CAS	182959-33-7
Molecular Formula	C21H21FN2O.ClH
MDL Number	MFCD06411577
Molecular Weight	372.869
MOL File	182959-33-7.mol

Chemical Properties

Melting point	236.5-237.2 °C
storage temp.	Store at -20°C
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 2 mg/ml
form	A crystalline solid
color	Off-white to light brown

Safety Data

Safety Statements

22-24/25

Hazard Information

Spectrum Detail

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Animal Model:	Sprague-Dawley (SD) rats weighing 150-170?g^[1]
Dosage:	6.25, 12.5, 25 or 50?mg/kg
Administration:	Given a single p.o.
Result:	Inhibited cholesterol biosynthesis from acetate in a dose-dependent manner in rats. The ED₅₀?value for YM-53601 cholesterol biosynthesis inhibition is 32? mg/kg.

Animal Model:	Five- to six-week-old male BALB/c athymic (nu/nu) nude mice^[4]
Dosage:	15 mg/kg
Administration:	2 wk of daily treatment by p.o. gavage
Result:	Significantly decreased the intratumor cholesterol levels.

182959-33-7

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