1821-13-2

A-1062 is a resolvase-binding inhibitor. A1062 inhibits resolvase binding to the res site.

A1062 is an inhibitor for Tn3 encoded resolvase with IC50 in micromolar level. A1062 suppresses the binding of resolvase proteins to res sites, and blocks resolvase-induced site-specific recombination[1].

[1] Flanagan PM, et al., Analysis of inhibitors of the site-specific recombination reaction mediated by Tn3 resolvase. J Mol Biol. 1989 Mar 20;206(2):295-304. DOI:10.1016/0022-2836(89)90479-8