1809170-59-9

Name	UniPR1331
CAS	1809170-59-9
Molecular Formula	C35H48N2O4
Molecular Weight	560.78
MOL File	1809170-59-9.mol

Synonyms

UniPR1331

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Chemical Properties

Boiling point	781.7±60.0 °C(Predicted)
density	1.21±0.1 g/cm3(Predicted)
form	Solid
pka	3?+-.0.10(Predicted)
color	White to light yellow

Hazard Information

Description

UniPR1331 is a novel selective antagonist of the Eph-ephrin system.

Uses

UniPR1331 is a 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 interacts with VEGFR2 and blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells in vitro. UniPR1331 also inhibits tumor cell-driven angiogenesis in zebrafish[1].

References

[1] Rusnati M, et al. Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin. Cancer Gene Ther. 2022 Jul;29(7):908-917. DOI:10.1038/s41417-021-00379-5

Supplier

Shanghai Yu Ben Biotechnology Co., Ltd.

Telephone021-61350663 15502154572

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList30592/0_EN.htm

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Shanghai Jianchao Biotechnology Co., LTD

Telephone15021035486 18081542813

Websitehttp://ats-mall.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Kangenbo Medical Technology Co., Ltd.

Telephone400-1388-521 17510465506

Website

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