ChemicalBook CAS DataBase List 1808-12-4

1808-12-4

Name	Bromazine Hydrochloride
CAS	1808-12-4
EINECS(EC#)	217-310-9
Molecular Formula	C17H21BrClNO
MDL Number	MFCD01727165
Molecular Weight	370.712
MOL File	1808-12-4.mol

Chemical Properties

Melting point	144-145°
storage temp.	Refrigerator
solubility	Acetone (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	Pale Yellow
BRN	3754363
Major Application	pharmaceutical (small molecule)
InChI	InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H
InChIKey	ZQDJSWUEGOYDGT-UHFFFAOYSA-N
SMILES	C(OCCN(C)C)(C1=CC=CC=C1)C1=CC=C(Br)C=C1.Cl

Safety Data

WGK Germany	WGK 1
HS Code	2922190900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Hazard Information

Description

Bromodiphenhydramine is a histamine H₁ receptor antagonist. It induces histamine release in isolated guinea pig lung when used at a concentration of 1 mM but completely prevents ovalbumin-induced histamine release in lungs isolated from ovalbumin-sensitized guinea pigs when used at concentrations of 100 and 200 μg/ml. Bromodiphenhydramine (17 mg/kg) inhibits formalin-induced paw edema in rats. It increases survival in a mouse model of systemic S. typhimurium infection when administered at doses of 1.5 and 3 mg/kg.

Uses

Antihistaminic.

Definition

ChEBI: The hydrochloride salt of bromazine. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies.

Brand name

Ambodryl.

General Description

Bromodiphenhydraminehydrochloride, 2-[(4-bromophenyl)-phenylmethoxy]-N, N-dimethylethanamine hydrochloride(Ambodryl Hydrochloride), is a white to pale buff crystallinepowder that is freely soluble in water and in alcohol.Relative to diphenhydramine, bromodiphenhydramine ismore lipid soluble and was twice as effective in protectingagainst the lethal effects of histamine aerosols.

References

[1] ABBAS AHMADI. Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.[J]. Mini reviews in medicinal chemistry, 2012, 12 12: 1282-1292. DOI: 10.2174/138955712802762013
[2] I. MOTA W. D D S. THE ANTI-ANAPHYLACTIC AND HISTAMINE-RELEASING PROPERTIES OF THE ANTIHISTAMINES. THEIR EFFECT ON THE MAST CELLS[J]. British Journal of Pharmacology, 1960, 15 3: 396-404. DOI: 10.1111/j.1476-5381.1960.tb01262.x
[3] SUJATA G. DASTIDAR. Antibacterial Activity of Ambodryl and Benadryl[J]. Journal of Applied Microbiology, 1976, 41 2: 209-214. DOI: 10.1111/j.1365-2672.1976.tb00621.x

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