1801338-22-6

AB-FUBICA (Item No. 18758) is an analytical reference material that is structurally categorized as a synthetic cannabinoid (CB). It is an indole-based CB with the structural groups found in AB-FUBINACA . The physiological and toxicological properties of this compound are not known. This product is intended for research and forensic applications.

AB-FUBICA (Compound 13) is a CB1 and CB2 receptor agonist that activates G-protein coupled inwardly rectifying potassium channels (GIRK) by binding to CB1 and CB2 receptors, displaying notable cannabinoid-like activity. AB-FUBICA has EC50 values of 21 nM for CB1 and 15 nM for CB2. AB-FUBICA may be suitable for studying pain management, neurodegenerative diseases, and inflammation-related mechanisms[1].

CB1: 21 nM (EC₅₀); CB2: 15 nM (EC₅₀)

[1] Banister SD, et al. Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. ACS Chem Neurosci. 2015 Sep 16;6(9):1546-59. DOI:10.1021/acschemneuro.5b00112