DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes[1][2].
in vivo
DiaPep277 (50 μg; i.p.; single dosage) causes strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses[2].
Animal Model:
Female NOD mice (diabetes model)[2]
Dosage:
50 μg
Administration:
i.p.; single dosage
Result:
Caused strong splenic T cells responses, and strong diabetogenic clones 27, C7, and C9 responses.
References
[1] Eldor R, et al. Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial results. Diabetes Metab Res Rev. 2009 May;25(4):316-20. DOI:10.1002/dmrr.942 [2] Elias D, et al. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3088-91. DOI:10.1073/pnas.88.8.3088
