178805-91-9
Synonyms
CAS
XPO2
CSE1
Exportin-2
CALCISEPTINE
CSE1 chromosome segregation 1-like
chromosome segregation 1-like protein
CALCISEPTINE, DENDROASPIS POLYLEPIS POLYLEPIS
Anti-CSE1L, N-Terminal antibody produced in rabbit
Calciseptine from Dendroaspis polylepis polylepis (black mamba)
ANTI-CELLULAR APOPTOSIS SUSCEPTIBILITY(C-TERMINAL) antibody produced in rabbit
ARG-ILE-CYS-TYR-ILE-HIS-LYS-ALA-SER-LEU-PRO-ARG-ALA-THR-LYS-THR-CYS-VAL-GLU -ASN-THR-CYS-TYR-LYS-MET-PHE-ILE-ARG-THR-GLN-ARG-GLU-TYR-ILE-SER-GLU-ARG-GLY-CYS-GLY-CYS-PRO-THR-ALA-MET-TRP-PRO-TYR-GLN-THR-GLU-CYS-CYS-LYS-GLY-ASP-CYS -ASN-LYS
Hazard Information
Uses
Calciseptine, a natural?neurotoxin?isolated from the black mamba Dendroaspis p. polylepis venom. Calciseptine consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type?calcium channel[1].
IC 50
L-type calcium channel: 15 nM (IC50)
References
[1] H Schweitz, et al. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3): 878–882. DOI:10.1073/pnas.91.3.878
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