1783800-77-0

Name	N-[3-(benzimidazol-1-yl)-1,4-dioxonaphthalen-2-yl]-4-nitrobenzenesulfonamide
CAS	1783800-77-0
Molecular Formula	C23H14N4O6S
Molecular Weight	474.45
MOL File	1783800-77-0.mol

Synonyms

N-[3-(benzimidazol-1-yl)-1,4-dioxonaphthalen-2-yl]-4-nitrobenzenesulfonamide Benzenesulfonamide, N-[3-(1H-benzimidazol-1-yl)-1,4-dihydro-1,4-dioxo-2-naphthalenyl]-4-nitro-

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Chemical Properties

form	Solid
color	Orange to red

Hazard Information

Uses

AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease[1].

in vivo

AUTEN-67 enhances autophagy in zebrafish (10, 50 μM)and mice (e 50 μmol/g body weight, i.p.)^[1].
AUTEN-67 (19 mg/kg, p.o., 3 times a week, for 3 month) restores nesting behavior and decreases APP level in the Alzheimer disease mice model^[1].

Animal Model:	Alzheimer disease model (Mice expressing the human APP)^[1]
Dosage:	19 mg/kg, 3 times a week for 3 month
Administration:	Oral administration
Result:	Restored nesting behavior by around 30%. Decreased Amyloid β levels in the hemibrain of mice.

References

[1] Papp D, et al. AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects. Autophagy. 2016;12(2):273-86. DOI:10.1080/15548627.2015.1082023

Supplier

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Telephone86-571-88216897,88216896 13588875226

Websitehttp://www.hzclap.com/en/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

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