178165-43-0

EMD-95885 is a selective NR2B-containing NMDA receptors antagonist with an IC50 of 3.9 nM. EMD-95885 does not interact with other sites on the NMDA receptor[1].

NR2B: 3.9 nM (IC₅₀)

[1] Roger G, et al. Radiosynthesis and pharmacological evaluation of [11C]EMD-95885: a high affinity ligand for NR2B-containing NMDA receptors. Bioorg Med Chem. 2004 Jun 15;12(12):3229-37. DOI:10.1016/j.bmc.2004.03.065