keenamide A
Cyclo[(4R)-2-[(1S)-1-amino-3-methylbutyl]-4,5-dihydro-4-thiazolecarbonyl-L-isoleucyl-L-prolylglycyl-O-(1,1-dimethyl-2-propen-1-yl)-L-seryl]
Keenamide A is a cytotoxic cyclic hexapeptide and exhibits significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive when evaluated against the D6 and W2 Plasmodium falciparum malarial clones.
