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7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC50 of 4.66 mM[1]. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells[2].

[1] Wang J, et al. Negative regulation of Toll-like receptor signaling pathway. Microbes Infect. 2009 Mar;11(3):321-7. DOI:10.1016/j.micinf.2008.12.011
[2] Aaftaab Sethi, et al. Non-carbohydrate strategies to inhibit lectin proteins with special emphasis on galectins. Eur J Med Chem. 2021 Oct 15:222:113561. DOI:10.1016/j.ejmech.2021.113561