1772-39-0

NSC-657186 is a novel selective non-zinc-binding MMP-2 inhibitor.

MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1].

MMP-2: 4.2 ± 0.2 μM (IC₅₀); MMP13: 12 ± 7 μM (IC₅₀); MMP-9: 23.3 ± 10. μM (IC₅₀); MMP-8: 25 ± 10 μM (IC₅₀)

[1] Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257. DOI:10.1016/j.bmc.2019.115257