175026-96-7

Apoptosis signal-regulating kinase 1 (ASK1) is the ubiquitously expressed mitogen-activated protein kinase kinase kinase 5 involved in a wide range of biological functions that are dependent on cell survival or death. NQDI-1 is a specific inhibitor of ASK1 (IC₅₀ = 3 μM; K_i = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases. It has been used to promote survival of induced pluripotent stem cell populations and to protect neurons from reactive oxygen species-induced apoptosis in a model of ischemia.

NQDI-1 is an ASK1 inhibitor which is of therapeutic potential against acute ischemic renal injury. ?Its protective effects are mediated through inhibition of apoptosis and oxidative stress.

Volynets et al. (2011), Identification of 2H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1); Med. Chem., 54 2680 Nomura et al. (2013), An ASK1-p38 signaling pathway mediates hydrogen peroxide-induced toxicity in NG108-15 neuronal cells; Lett., 549 163 Chen et al. (2019), The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage; J. Pharmacol., 176 1341 Ma et al. (2019), Low glucose and metformin-induced apoptosis of human ovarian cancer cells is connected to ASK1 via mitochondrial and endoplasmic reticulum stress associated pathways; Exp. Clin. Cancer Res., 38 77 Feng et al. (2018), Dual function of peroxiredoxin I in lipopolysaccharide-induced osteoblast apoptosis via reactive oxygen species and the apoptosis signal-regulating kinase 1 signaling pathway; Cell Death Discov., 4 47