ChemicalBook CAS DataBase List 174362-95-9

174362-95-9

Name	Amino-Tri-(carboxyethoxymethyl)-methane
CAS	174362-95-9
Molecular Formula	C13H23NO9
MDL Number	MFCD31615450
Molecular Weight	337.32
MOL File	174362-95-9.mol

Chemical Properties

Boiling point	620.2±55.0 °C(Predicted)
density	1.350±0.06 g/cm3(Predicted)
solubility	Soluble in Water, DMSO, DCM, DMF
form	low melting solid
pka	3.74±0.10(Predicted)
color	Colourless

Hazard Information

Description

Amino-Tri-(carboxyethoxymethyl)-methane is a branched molecule that is reactive towards carboxylic acids in the presence of HATU. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Amino-Tri-(carboxyethoxymethyl)-methan is a cleavable PEG-based ADC linker that can be used to synthesize antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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