17365-01-4

Tan Solid

Derivative of thyroxine. Antilipemic

Skleronorm,Gruenenthal,W. Germany,1977

ChEBI: Etiroxate is an aromatic ether.

7.91 g of α-methyl thyroxine are suspended in 150 cc of ethanol. While heating, the solution is saturated with dry hydrogen chloride. Thereafter, the solvent is distilled off at reduced pressure. The residue is dissolved in a mixture of ethanol and water (1:1). Adding a 5% solution of sodium hydrogen carbonate in water, the ethyl ester of α-methyl thyroxine precipitates; melting point: 156°C to 157°C after recrystallization from ethanol. The yield is 6.05 g, i.e., 74% of the theoretical yield.

Antihyperlipoproteinemic