17140-71-5

Name	5-Iodo-2'-deoxyuridine (hydrate)
CAS	17140-71-5
Molecular Formula	C9H13IN2O6
Molecular Weight	372.12
MOL File	17140-71-5.mol

Synonyms

Idoxuridine (hydrate) 5-Iodo-2'-deoxyuridine (hydrate) URIDINE,2'-DEOXY-5-IODO-, MONOHYDRATE (8CI,9CI) 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione:hydrate

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Hazard Information

Uses

Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1].

in vivo

Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) hydrate can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice^[2].

Animal Model:	C3HeB/FeJ female and male mice and A/J male mice, aged 2 to 4 months^[2]
Dosage:	50-200 mg/kg
Administration:	Intraperitoneal injection, 3 times, 3 hours interval
Result:	Stimulated the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in the dose range of 50-200 mg/kg.

References

[1] ]David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. DOI:10.2460/ajvr.2004.65.399
[2] D E Griswold, et al. Stimulation of hemolysin plaque-forming cells by idoxuridine. Cancer Res. 1975 Jan;35(1):88-92. PMID:1089043

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SPIRO PHARMA

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Websitehttp://www.spiropharma.com.cn

TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

Hangzhou MolCore BioPharmatech Co.,Ltd.

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Websitehttps://www.molcore.com/

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