171202-16-7

bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC₅₀ = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC₅₀ = 343 nM), and PTP-1β (IC₅₀ = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.

bpV(phen) (Potassium Hydrate) inhibits several different protein tyrosine phosphatases (PTPs).

Leishmania

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