170856-41-4

Name	PNU 96415E
CAS	170856-41-4
Molecular Formula	C21H26ClFN2O
MDL Number	MFCD00940853
Molecular Weight	376.9
MOL File	170856-41-4.mol

Synonyms

PNU 96415E 1-[2-(3,4-DIHYDRO-1H-2-BENZOPYRAN-1-YL)ETHYL]-4-(4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE

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Chemical Properties

storage temp.	Desiccate at RT
form	Powder
Water Solubility	Soluble to 10 mM in water

Hazard Information

Uses

PNU 96415E is an antipsychotic agent; SR-2A inhibitor.

Biological Activity

Antipsychotic agent. Displays high affinity for dopamine D 4 and serotonergic 5-HT 2A receptors and relatively weak affinity at D 2 receptors (K i values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D 4 , 5-HT 2A , 5-HT 1A , α 1 , D 2 , D 3 , D 1 , α 2 ? and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

in vivo

PNU-96415E blockes 5-HTP-induced bead twitches in mice and stereotypic behaviours produced by high doses of amphetamine and methylphenidate^[1].

IC 50

D₄ Receptor; 5-HT_2A Receptor

storage

Desiccate at RT

Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

MedBioPharmaceutical Technology Inc

Telephone021-69568360 18916172912

Websitehttp://www.med-bio.cn/

Energy Chemical

Telephone021-58432009 400-005-6266

Websitehttp://www.energy-chemical.com

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Wuhan Topule Biopharmaceutical Co., Ltd

Telephone +86-18327326525

Websitehttp://topule.com/

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