ChemicalBook CAS DataBase List 170142-20-8

170142-20-8

Name	ZD 9379
CAS	170142-20-8
Molecular Formula	C19H14ClN3O4
MDL Number	MFCD27991266
Molecular Weight	383.79
MOL File	170142-20-8.mol

Chemical Properties

density	1.54±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	<19.19mg/ml in DMSO; <7.68mg/ml in 1eq. NaOH
pka	9.25±0.20(Predicted)

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Shanghai EFE Biological Technology Co., Ltd.

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Jinan Yaoyan Pharmaceutical Co., Ltd.

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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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MedBioPharmaceutical Technology Inc

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Energy Chemical

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TargetMol Chemicals Inc.

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Suzhou Meishi Biotechnology Co., Ltd.

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Nantong QuanYi Biotechnology Co., Ltd

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Chengdu Peter-like Biotechnology Co., Ltd.

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Alomone Labs

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Biosynth Biological Technology (Suzhou) Co Ltd

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Websitehttp://www.biosynth.com

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Animal Model:	Male Sprague-Dawley rats weighing 290 to 340 g undergoing permanent middle cerebral artery occlusion (MCAO)^[1]
Dosage:	5 mg/kg
Administration:	Group1: a 5-mg/kg bolus of ZD-9379 over 5 minutes followed by 5 mg/kg per hour drug infusion for 4 hours beginning 30 minutes before MCAO. Group 2: (post-MCAO treatment group), a 5-mg/kg bolus of ZD-9379 30 minutes after MCAO followed by 5 mg/kg per hour drug infusion for 4 hours.
Result:	Initiated before or after MCAO significantly reduced the number of Spreading depressions (SDs) and infarct volume in a permanent focal ischemia model.

170142-20-8

Chemical Properties

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in vivo

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