169799-04-6

CGS 27023A is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis[1].

stromelysins 1: 43 nM (Ki); collagenases 1: 33 nM (Ki); MMP-2: 20 nM (Ki); MMP-9: 8 nM (Ki)

[1] MacPherson LJ, et al. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem. 1997;40(16):2525-2532. DOI:10.1021/jm960871c