Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC50 values of 10, 25, 94 μM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively[1].
IC 50
Topoisomerase II: 10 μM (IC50); DNA Polymerase α: 25 μM (IC50); DNA Polymerase β: 94 μM (IC50)
References
[1] Mizushina Y, et al. Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, selectively inhibits the activities of mammalian DNA polymerases and human DNA topoisomerase II. Biochem Biophys Res Commun. 2000 Jul 5;273(2):784-8. DOI:10.1006/bbrc.2000.3007
