166374-48-7

Adentri, also known as BG-9719 and CVT-124, is a novel adenosine A1 receptor antagonist with unique diuretic activity.

Adentri (CVT-124) is a potent and A1-adenosine selective antagonist with a Ki of 0.45 nM at cloned human A1-receptors. Adentri can be utilized in cardiovascular research[1].

[1] Pfister JR, et al. Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine. J Med Chem. 1997 Jun 6;40(12):1773-8. DOI:10.1021/jm970013w