ChemicalBook CAS DataBase List 164991-67-7

164991-67-7

Name	KukoaMine B
CAS	164991-67-7
Molecular Formula	C28H42N4O6
MDL Number	MFCD29904539
Molecular Weight	530.66
MOL File	164991-67-7.mol

Chemical Properties

Boiling point	844.3±65.0 °C(Predicted)
density	1.232±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	-20°C
solubility	DMF:30.0(Max Conc. mg/mL);56.53(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);56.53(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);56.53(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);18.84(Max Conc. mM) Water:62.5(Max Conc. mg/mL);117.78(Max Conc. mM)
form	A crystalline solid
pka	9.78±0.10(Predicted)
color	White to off-white
Major Application	food and beverages
InChIKey	IWRAOCFRRTWUDF-UHFFFAOYSA-N
SMILES	C1(CCC(N(CCCN)CCCCNCCCNC(=O)CCC2=CC=C(O)C(O)=C2)=O)=CC=C(O)C(O)=C1

Safety Data

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Hazard Information

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the bark of Lycium bark.

Uses

Kukoamine B is an amide alkaloiad used in the protection against NMDA-induced neurotoxicity and potential harmful mechanisms. In addition it is seen to inhibit the inflammatory response in the livers of septic mice.

Definition

ChEBI: Kukoamine B is an amine.

in vivo

Kukoamine B (20, 50 mg/kg, i.g., daily, 9 weeks) reduces inflammation and blood glucose without body weight gain or liver mass increase^[1].
Kukoamine B (2, 5 mg/kg, p.o., daily, 12 weeks) demonstrates the anti-osteoporotic effects in ovariectomized (OVX) mice^[3].
Kukoamine B (1.25-60 mg/kg, i.v., only one injection or very 8 h for 3 days) protects mice challenged with E. coli and reduces the circulatory levels of LPS and TNF-a in sepsis model mice^[4].

Animal Model:	Male, 4-week old db/db mice (BKS.Cgm+/+Leprdb/J) and wildtype (WT) mice (C57BLKS/J-m+/+ db). A spontaneous type 2 diabetic animal model^[1].
Dosage:	20, 50 mg/kg
Administration:	i.g., daily, 9 weeks
Result:	Successfully controlled the augment of blood glucose with age increase. Reduced levels of 29 inflammatory markers such as IL-2, IL-3, IL-4, IL-5, IL-6, IL-7 and IL8.

Animal Model:	Seven-week-old female ddy mice underwent either an ovariectomy or sham-operated surgery^[3].
Dosage:	2, 5 mg/kg
Administration:	p.o., daily, 12 weeks
Result:	Inhibited the OVX-induced BMD loss in the right femur bone and restored the impaired bone structural properties of BV/TV, Tb.Th, Tb.N, and Tb.Sp.

Animal Model:	Kunming (KM) mice, 4–6 weeks old, 18–20 g, male and female in equal number. Mice were injected with heat-killed E. coli (EC, 1.0 * 10¹¹ CFU?kg_-1) in order to establish the sepsis model.^[4].
Dosage:	1.25, 2.5, 5, 10, 15, 30, 60 mg/kg
Administration:	80 mice (15, 30, 60 mg/kg), i.v., only one injection; 100 mice (1.25, 2.5, 5 mg/kg), i.v., every 8 h for 3 days; 96 mice, (60 mg/kg), i.v., once at 0, 2, 4, 6, 8 h after injection of EC.
Result:	Significantly decreased the mortality rate from 87.5% to 62.5%, 62.5%, or 37.5% (15, 30, 60 mg/kg). Decreased the mortality rate from 95% to 65%, 60% and 45% (1.25, 2.5 and 5 mg/kg). Decreased the circulatory LPS and TNF-a levels in a time-dependent manner.

Spectrum Detail

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