1620523-64-9

Azide-SS-biotin is a cleavable biotinylation reagent for labeling alkyne-containing biomolecules using click chemistry. The azide group reacts with alkynes, DBCO or BCN reagent to form a stable triazole linkage. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.

Azide-C2-SS-C2-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azide-C2-SS-C2-biotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Disulfide Cleavable Linker; Cleavable Linker

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268