ChemicalBook CAS DataBase List 1618672-71-1

1618672-71-1

Name	1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene
CAS	1618672-71-1
Molecular Formula	C22H12Cl4N2O4
MDL Number	MFCD29081185
Molecular Weight	510.15
MOL File	1618672-71-1.mol

Chemical Properties

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

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Animal Model:	A549 Lung cancer xenograft model in mice^[2]
Dosage:	20 mg/kg, 40 mg/kg
Administration:	ip; 5 times per weeks, 27 days; with or without ONC201 (i.p.; 25?mg/kg, 1 time a week).
Result:	Dose-dependently inhibited the tumor growth, and sensitized tumors to TRAIL. Induced tumor expression of TRAIL, DR5 and the level of cleaved caspase-7 and H3K9me3, whereas decreased the expression of KDM4A in xenograft tumors.