161187-57-1

Name	3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
CAS	161187-57-1
Molecular Formula	C20H23NO6
Molecular Weight	373.4
MOL File	161187-57-1.mol

Synonyms

αGlucosidaseIN23 α-Glucosidase-IN-23 α-Glucosidase-IN-23, 10 mM in DMSO 3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

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Chemical Properties

Boiling point	481.5±45.0 °C(Predicted)
density	1.225±0.06 g/cm3(Predicted)
pka	3.06±0.70(Predicted)

Hazard Information

Uses

α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1].

in vivo

α-Glucosidase-IN-23 (oral; 0.2 mmol/kg/day) only inhibits a-glucosidase in mice^[1].

Animal Model:

Mice^[1]

Dosage:

0.2 mmol/kg

Administration:

Oral; 0.2 mmol/kg/day

Result:

C_max (nmol/mL)	T_max (h)	T_1/2(h)	AUC (ng/h/mL)
10.11 ± 1.17	0.8 ± 0.0	1.90 ± 1.04	36.7 ± 2.23

References

[1] Peter A Sidhom, et al. Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species. J Med Chem. 2023 Jan 12;66(1):991-1010. DOI:10.1021/acs.jmedchem.2c01818

Spectrum Detail

3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester(161187-57-1)¹HNMR

Supplier

Tianjin Kailiqi Biotechnology Co., Ltd.

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Shanghai Yifei Biotechnology Co. , Ltd.

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