1604678-82-1

Name	PQA-18
CAS	1604678-82-1
Molecular Formula	C25H31NO4
Molecular Weight	409.52
MOL File	1604678-82-1.mol

Synonyms

PQA-18 2-Quinolinecarboxylic acid, 4,8-bis[(3-methyl-2-buten-1-yl)oxy]-, 3-methyl-2-buten-1-yl ester

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Chemical Properties

Boiling point	545.702±45.00 °C(Press: 760.00 Torr)(predicted)
density	1.075±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
form	Solid
pka	3.055±0.10(predicted)
color	Light yellow to yellow

Hazard Information

Uses

PQA-18 is a unique PAK2 inhibitor (IC50: 10 nM). PQA-18 has immunosuppressing effects. PQA-18 suppresses IL2, IL4, IL6, and TNFα. PQA-18 inhibits the population of a subset of regulatory T cells and the immunoglobulin (Ig) production against T cell-dependent antigens as well as alleviates dermatitis in mice[1].

in vivo

PQA-18 (0.5 mg/kg, i.p., three times a week) displays immunosuppressing activity in C57BL/6J mice immunized with NP-CGG, with inhibiting the population of a subset of regulatory T cells and the immunoglobulin (Ig) production against T cell-dependent antigens^[1].
PQA-18 ointment (100 mg/mouse, contains 0.05%-0.1% PQA-18, three times a week, 17 weeks) improves dermatitis and IgE levels in Nc/Nga mice^[1].

Animal Model:	Male C57BL/6J mice (10 weeks old) immunized by intraperitoneal injection of 50 μg NP-CGG^[1]
Dosage:	0.5 mg/kg
Administration:	Intraperitoneal injection (i.p.); three times a week
Result:	Suppressed the NP-specific responses (IgM, IgG1, and IgG3) in peripheral blood. Significantly suppressed the number of Foxp3⁺CD4⁺CD25⁺ cells in spleens.

IC 50

PAK2: 10 nM (IC₅₀); IL-6; IL4; IL-2

References

[1] Ogura M, et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65. DOI:10.1016/j.bcp.2016.01.020

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Cayman Chemical Company

Telephone800-364-9897

Websitehttp://www.caymanchem.com

Zhejiang Huida Biotech Co., Ltd.

Telephone0571-89903022 18679456698

Websitehttps://www.huidacollection.cn

Shenzhen Campbell Biotechnology Co., Ltd.

Telephone18028747627

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1668922/0_EN.htm

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