159776-68-8

Name	Linetastine
CAS	159776-68-8
Molecular Formula	C35H40N2O6
Molecular Weight	584.7
MOL File	159776-68-8.mol

Synonyms

Linetastine Unii-7U248Z56la Linetastine [inn] [4-[(1E,3E)-5-[2-(4-benzhydryloxypiperidin-1-yl)ethylamino]-5-oxopenta-1,3-dienyl]-2-methoxyphenyl] ethyl carbonate Carbonic acid, 4-[(1E,3E)-5-[[2-[4-(diphenylmethoxy)-1-piperidinyl]ethyl]amino]-5-oxo-1,3-pentadien-1-yl]-2-methoxyphenyl ethyl ester

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Chemical Properties

Boiling point	760.9±60.0 °C(Predicted)
density	1.20±0.1 g/cm3(Predicted)
pka	14.19±0.46(Predicted)

Hazard Information

Uses

Linetastine is an orally active and potent 5-Lipoxygenase inhibitor. Linetastine shows antihistamine activity. Linetastine inhibits leukotriene production and antagonizes the effect of histamine. Linetastine inhibits the release of leukotrienes B4 and C4 from calcium ionophore-stimulated human leukocytes[1].

in vivo

Linetastine inhibits histamine-induced bronchoconstriction dose-dependently at 1-10 mg/kg (p.o.) in guinea-pigs, and the effect lasts for more than 24 h^[1].

IC 50

5-Lipoxygenase; Histamine Receptor

References

[1] Shizawa T, et al. 5-Lipoxygenase inhibitory and antihistamine activities of linetastine. Arzneimittelforschung. 1996 Nov;46(11):1072-6. PMID:8955867

Spectrum Detail

Linetastine(159776-68-8)¹HNMR

Supplier

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Beijing Boorsen Biotechnology Co., Ltd

Telephone400-901-9800 18611424007

Websitehttp://www.bioss.com.cn/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

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