159659-05-9

Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 μM for branched chain amino acid preferring, 2.3 μM for small neutral amino acid preferring, and 40.5 μM for chymotrypsin-like activities; IC50 = 3.1 μM for peptidyl-glutamyl peptide hydrolyzing activity)[1].

[1] M Orlowski, et al. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 1997 Nov 11;36(45):13946-53. DOI:10.1021/bi970666e