1594427-18-5

Viral 2C protein inhibitor 1 (compound 6aw) is a potent and broad-spectrum enterovirus antiviral agent, inhibiting viral 2C protein. Viral 2C protein inhibitor 1 inhibits multiple strains of EV-D68, EV-A71 and CVB3 with EC50s of 0.1~3.6 μM, and exhibits high selectivity index and relatively low cytotoxicity[1].

[1] Musharrafieh R, et al. Development of broad-spectrum enterovirus antivirals based on quinoline scaffold. Bioorg Chem. 2020 Aug;101:103981. DOI:10.1016/j.bioorg.2020.103981