15903-94-3

Colourless Crystalline Solid

Indole derivative, as antiviral and antitumor agent

The compound (CAS: 153805-86-8) was used as starting material and synthesized by a method similar to Example 32. The specific operation was as follows: 5% rhodium/carbon powder was added to the reaction system as a catalyst, and the metal compounds ferrous acetate (II), nickel nitrate (II) or cobalt acetylacetonate (III) were introduced as co-catalysts. 5-Benzyloxy-2-(2-pyrrolidinylvinyl)nitrobenzene was used as the substrate for the reduction reaction. Upon completion of the reaction, as shown in Table 6, the yield of 6-benzyloxyindole was significantly increased and the by-product yield of 6-hydroxyindole was decreased when the reducing agent of the present invention was used as compared to the counterpart 5.

[1] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 39-40
[2] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 39-40
[3] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 39-40
[4] Patent: EP1541582, 2005, A1. Location in patent: Page/Page column 39-40
[5] Organic Process Research and Development, 2006, vol. 10, # 6, p. 1178 - 1183