159013-54-4

BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect[1][2].

Mixed non-peptide neuropeptide Y Y 1 (NPY Y 1 ) and neuropeptide FF (NPFF) receptor antagonist (K i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y 1 , hNPFF 2 , rNPFF, rNPY Y 2 , rNPY Y 4 and rNPY Y 5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Selective non-peptide neuropeptide Y1 (NPY1) receptor antagonist.

[1] Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4. DOI:10.1038/sj.bjp.0704049