CHIR-2279 is a high-affinity ligand (Ki=5 nM) for the α1-adrenergic receptor and can be further studied as a drug lead compound[1].
IC 50
α1-adrenergic receptor: 5 nM (Ki)
References
[1] Zuckermann, et al. Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted) glycine peptoid library. Journal of medicinal chemistry 37.17 (1994): 2678-2685. DOI:10.1021/jm00043a007
