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THK-523 is a selective Tau ligand, selectively binding to neurofibrillary tangles and neuropils in people with Alzheimer's disease.

THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].

[1] Ryuichi Harada, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging.?2013 Jan;40(1):125-32. DOI:10.1007/s00259-012-2261-2
[2] Michelle T Fodero-Tavoletti,?18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain.?2011 Apr;134(Pt 4):1089-100. DOI:10.1093/brain/awr038