157254-60-9

1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

iNOS: 7.6 nM (Ki); eNOS: 360 nM (Ki); nNOS: 16 nM (Ki)

Store at -20°C