157148-06-6

Name	harzianic acid
CAS	157148-06-6
Molecular Formula	C19H27NO6
MDL Number	MFCD01759365
Molecular Weight	365.42
MOL File	157148-06-6.mol

Synonyms

harzianic acid 2-Pyrrolidinepropanoic acid, α-hydroxy-4-[(2E,4E)-1-hydroxy-2,4-octadien-1-ylidene]-1-methyl-α-(1-methylethyl)-3,5-dioxo-, (αS,2S,4Z)-

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Chemical Properties

Melting point	85-86 °C(Solv: ethyl acetate (141-78-6))
Boiling point	619.6±55.0 °C(Predicted)
density	1.225±0.06 g/cm3(Predicted)
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	3.75±0.32(Predicted)

Hazard Information

Description

Harzianic acid is a Trichoderma secondary metabolite. Harzianic acid shows plant growth promotion activity. 3. Harzianic acid has antifungal activity and antibiotic activity against Pythium irregulare, Sclerotinia sclerotiorum, and Rhizoctonia solani.

Uses

Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2].

target

Antifection

References

[1] De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445. DOI:10.1080/14786419.2020.1779714
[2] Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988. DOI:10.1021/jacs.1c03988. doi: 10.1021/jacs.1c03988

Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.

Telephone028-81700200 18116577057

Websitehttps://www.weikeqi-biotech.com/

Wuhan ChemFaces Biochemical Co., Ltd.

Telephone18607101326 15172504745

Websitehttp://www.chemfaces.com

Wuhan Zhongzhicheng Biotechnology Co., Ltd.

Telephone13628624121 13628604890

Websitehttps://www.whherb.cn

Hangzhou MolCore BioPharmatech Co.,Ltd.

Telephone+86-057181025280; +8617767106207

Websitehttps://www.molcore.com/

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