157124-84-0

Name	1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassiuM salt
CAS	157124-84-0
Molecular Formula	C16H16K3O7PS
MDL Number	MFCD25976798
Molecular Weight	500.628
MOL File	157124-84-0.mol

Synonyms

BPH-652 FIOQVVKPUBNHEM-UHFFFAOYSA-N 1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassiuM salt

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Chemical Properties

storage temp.	4°C, away from moisture
form	Solid
color	White to off-white
Water Solubility	Water : 25 mg/mL (49.94 mM; Need ultrasonic)

Hazard Information

Uses

BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation)[1].

in vivo

BPH-652 treatment (0.5 mg twice per day (days ?1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureusbacterial counts in the kidneys of the mice than those of the control group (P < 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group^[1].

Animal Model:	A systemic S. aureus infection model in mice^[1].
Dosage:	0.5 mg twice per day (days ?1, 0, 1, and 2).
Administration:	Intraperitoneal injection.
Result:	S. aureus bacterial counts in the kidneys of the mice treated with BPH-652 were significantly lower than those of the control group.

References

[1] Liu CI, et al. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 7;319(5868):1391-4. DOI:10.1126/science.1153018

Supplier

SPIRO PHARMA

Telephone

Websitehttp://www.spiropharma.com.cn

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840 15801484223;

Websitehttp://www.jm-bio.com/

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Guangzhou Yiran Biotechnology Co., Ltd.

Telephone15571990006

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1130802/0_EN.htm

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