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ChemicalBook CAS DataBase List 156679-34-4

156679-34-4 Structure

156679-34-4

Name	Lenercept
CAS	156679-34-4

Synonyms

Lenercept Research Grade Lenercept Research Grade Lenercept (DHB94410)

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Hazard Information

Uses

Immunomodulator.

in vivo

Lenercept (Ro 45-2081) inhibits Sephadex-induced lung injury in the rat^[1].
Lenercept (TNFR-IgG; 0.8-20 μg/mouse; i.v.; once) can prevent or significantly delay endotoxin-induced lethality in mice when given prior to or shortly after endotoxin challenge^[2].

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	1 and 3 mg/kg
Administration:	Intraperitoneal injection, 1 h before administration of Sephadex for the 24 h study or 1 h before and at 24 and 48 h after Sephadex for the 72 h study
Result:	Inhibited the neutrophilia at 24 h after Sephadex. At 72 h after Sephadex, significantly reduced the neutrophil influx into bronchoalveolar lavage fluid (BALF) but had no inhibitory effect on eosinophil number.

Animal Model:	6- to 8-week-old female BALB/c mice, septic shock model^[2]
Dosage:	0.8, 4 or 20 μg/mouse
Administration:	IV, single dose
Result:	Injection 0.5 h prior to Salmonella abortus-derived endotoxin (LD₁₀₀ dose) administration prevented lethality at a dose of 20 μg per mouse and provided partial protection at lower doses. Injection of 10 μg per mouse provided significant protection 0.5 h before, 0.5 h after, or 1 h after endotoxin injection but little protection 2 h after endotoxin injection.

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