p53 (232-240) is a peptide segment of the 232-240 amino acid sequence of the human tumor suppressor protein p53. p53 (232-240) enhances its binding affinity to the Major histocompatibility complex (MHC), thereby enhancing the immunogenicity of this peptide to enhance the immune system's response to tumor antigens. p53 (232-240) can be used in the development of cancer vaccines and in the study of tumor cell recognition and clearance by the immune system[1].
References
[1] Baratin M, et al. Amino acid modifications in the wild type sequence p53 232–240 overcome the poor immunogenicity of this self tumour epitope[J]. Journal of Peptide Science: An Official Publication of the European Peptide Society, 2002, 8(7): 327-334. DOI:10.1002/psc.391
