15503-87-4

A poison.

A pyrrolizidine alkaloid first isolated from Crotalaria usararnoensis E. G. Baker, this base has more recently been found in C. brevifolia and C. rnucronata. The alkaloid has [α]²⁰_D + 6.1° (c 0.38, EtOH) or + 7.1° (c 1.83, EtOH). It yields a picrate, m.p. 230- 2°C (dec.); picrolonate, m.p. 148-150°C (dec.); reineckate, m.p. 190-2°C (dec.) and methiodide, m.p. 229-230°C (dec.). Alkaline hydrolysis furnishes retronecine and retronecic acid, m.p. 177-9°C. It has been suggested that the base may be identical with Mucronatine (q.v.).

Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria[1].

ChEBI: LSM-2938 is a macrolide.

Culvenor, Smith., Austral. J. Chern., 19,2127 (1966)
Sawhney et al., Ind. J. Chern., 5, 655 (1967)