152881-18-0

Name	KF 17837
CAS	152881-18-0
Molecular Formula	C20H26N4O4
MDL Number	MFCD22493499
Molecular Weight	386.44
MOL File	152881-18-0.mol

Synonyms

KF 17837 KF 17837S 8-(3,4-Dimethoxyphenyl)-7-methyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione 1H-Purine-2,6-dione,8-(3,4-diMethoxyphenyl)-3,7-dihydro-7-Methyl-1,3-dipropyl

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Hazard Information

Description

KF 17837S is an adenosine A(2a) receptor antagonists, which is potential therapeutic and neuroprotective effects in Parkinson's disease.

in vitro

The novel A2A receptor antagonist, (E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine (KF 17837), blocked the CGS 21680 (1 nM)-induced inhibition of [3H]-GABA efflux with an EC50 of approximately 30 nM and also antagonized the CGS 21680 (0.1 nM)-induced stimulation of [3H]-ACh release with an EC50 of approximately 0.3 nM._x000D_ _x000D_ Reference: Br J Pharmacol. 1994 Sep;113(1):43-8. https://pubmed.ncbi.nlm.nih.gov/7812630/

in vivo

Autoradiographic study of [3H]KF17837S binding using rat brain sections revealed that the binding site was highly enriched in the striatal region. These data indicate that [3H] KF17837S labels the adenosine A2A receptor in rat brain._x000D_ _x000D_ Reference: Mol Pharmacol. 1994 Nov;46(5):817-22. https://pubmed.ncbi.nlm.nih.gov/7969067/

target

KF 17837S is an adenosine A(2a) receptor antagonists.

Supplier

Beijing Yisiyan Technology Research Center

Telephone010-56645598 13366904824;

Websitehttp://www.bjkaida.cn

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Telephone0731-85567275 19313119732

Websitehttp://www.chemfish.com/

Beijing Biocreative Technology Co., Ltd.

Telephone 15522676233

Websitehttp://www.bestbaiao.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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