150586-58-6

Name	4-(2-ethyl-5-fluoro-1,3-dihydroinden-2-yl)-3H-imidazole
CAS	150586-58-6
Molecular Formula	C14H15FN2
MDL Number	MFCD00922400
Molecular Weight	230.28
MOL File	150586-58-6.mol

Synonyms

JP1730 JP-1730 JP 1730 fipamezole 4-(2-ethyl-5-fluoro-1,3-dihydroinden-2-yl)-3H-imidazole 1H-Imidazole, 5-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-

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Hazard Information

Uses

Fipamezole (MPV 1730; JP-1730) is a potent and orally active α2-adrenergic receptor antagonist with Ki values of 9.2 nM, 17 nM, and 55 nM for human α2A, α2B, and α2C, receptors, respectively. Fipamezole is an anti-dyskinetic agent, and can be used for the study of Parkinson's disease[1].

in vivo

In the MPTP-lesioned marmoset, Fipamezole (1-10 mg/kg; po; once) significantly reduces L-dopa-induced dyskinesia without compromising the anti-parkinsonian action of L-DOPA (HY-N0304)^[1].

Animal Model:	Adult common marmosets (Callithrix jacchus, 300-345 g) injected with MPTP hydrochloride (2 mg/kg) and L-DOPA (8 mg/kg)^[1]
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	po; once
Result:	Significantly reduced L-DOPA-induced dyskinesia.

IC 50

human α2A-adrenoceptor: 9.2 nM (Ki); human α2B-adrenoceptor: 17 nM (Ki); human α2C-adrenoceptor: 55 nM (Ki)

References

[1] Juha-Matti Savola, et al. Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Mov Disord. 2003 Aug;18(8):872-83. DOI:10.1002/mds.10464

Spectrum Detail

4-(2-ethyl-5-fluoro-1,3-dihydroinden-2-yl)-3H-imidazole(150586-58-6)¹HNMR

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

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