150272-33-6
| Molecular Weight | 274.33 |
Synonyms
Benzyl-PEG2-MS
Benzyl-PEG3-Mes
CAS_150272-33-6
Benzyl-PEG2-Mes
2-(2-Phenylmethoxyethoxy)ethyl methanesulfonate
di(ethylene glycol)monobenzyl ether methanesulfonate
Ethanol, 2-[2-(phenylmethoxy)ethoxy]-, methanesulfonate
Ethanol, 2-[2-(phenylmethoxy)ethoxy]-, 1-methanesulfonate
Hazard Information
Uses
Benzyl-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity
Benzyl-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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