149759-26-2

LOE 908 Hydrochloride is a isoquinoline derivative and a cation channel blocker. LOE 908 Hydrochloride is a neuroprotective agent.

Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na + and K + channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.