149759-26-2

Name	LOE 908 HYDROCHLORIDE
CAS	149759-26-2
Molecular Formula	C41H48N2O9
MDL Number	MFCD09038554
Molecular Weight	712.83
MOL File	149759-26-2.mol

Synonyms

LOE 908 Pinokalant LOE 908 HYDROCHLORIDE 1-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]- 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamidehydrochloride

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Chemical Properties

Boiling point	803.7±65.0 °C(Predicted)
density	1.17±0.1 g/cm3(Predicted)
storage temp.	Desiccate at RT
form	Solid
pka	5.47±0.20(Predicted)
color	Off-white to light yellow

Hazard Information

Uses

LOE 908 Hydrochloride is a isoquinoline derivative and a cation channel blocker. LOE 908 Hydrochloride is a neuroprotective agent.

Biological Activity

Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na + and K + channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.

in vivo

Pinokalant significantly reduces cortical infarct volume from 33.8 mm³ to 24.5 mm³^[1].

Supplier

Telephone821-50328103-801 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Career Henan Chemica Co

Telephone+86-0371-86658258 +8613203830695

Websitehttps://www.coreychem.com/

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

Sangon Biotech (Shanghai) Co.,Ltd.

Telephone400-821-026

Websitehttp://www.sangon.com

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