Description
Mer-NF5003F is a sesquiterpene originally isolated from
Stachybotrys with diverse biological activities.
1,2,3 It inhibits avian myeloblastosis virus (AMV) protease (IC
50 = 7.8 μM).
1 Mer-NF5003F inhibits sialyltransferase 6N (ST6N), ST3O, and ST3N (IC
50s = 0.61, 6.7, and 10 μg/ml, respectively), as well as fucosyltransferase (IC
50 = 11.3 μg/ml).
2 It is active against herpes simplex virus 1 (HSV-1)
in vitro (IC
50 = 4.32 μg/ml).
3 Mer-NF5003F is also active against the multidrug-resistant
P. falciparum strain K1 (IC
50 = 0.85 μg/ml).
Uses
Mer-NF5003F (Stachybotrydial; F 1839M), a sesquiterpene isolated from Stachybotrys, inhibits avian medulloblastoma virus (AMV) protease (IC50=7.8 μM). Mer-NF5003F inhibits sialyltransferase 6N (ST6N), ST3O, and ST3N (IC50=0.61, 6.7, and 10 μg/mL, respectively), and fucosyltransferase (IC50=11.3 μg/mL). Mer-NF5003F has in vitro activity against herpes simplex virus HSV-1 (IC50=4.32 μg/mL) and multidrug-resistant Plasmodium falciparum K1 strain (IC50=0.85 μg/mL).
References
1. Kaneto, R., Dobashi, K., Kojima, I., et al. Mer-NF5003B, E and F, novel sesquiterpenoids as avian myeloblastosis virus protease inhibitors produced by Stachybotrys sp J. Antibiot. (Tokyo) 47(6),727-730(1994).
2. Lin, T.-W., Chang, W.-W., Chen, C.-C., et al. Stachybotrydial, a potent inhibitor of fucosyltransferase and sialyltransferase Biochem. Biophys. Res. Commun. 331(4),953-957(2005).
3. Sawadjoon, S., Kittakoop, P., Isaka, M., et al. Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora Planta Med. 70(11),1085-1087(2004).
