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5-Octyl D-glutamate, also known as 5-octyl ester D-glutamate, is a stable, cell-permeable molecule that generates free D-glutamate upon hydrolysis of the ester bond by cytoplasmic esterases. It may be used to increase levels of cytoplasmic D-glutamate. This compound is useful in studies examining the cellular effects of 5-octyl L-glutamate or 5-octyl α-ketoglutarate .

5-Octyl D-Glutamate acts as a stable cell permeable molecule which generates free D-glutamate upon digestion by the cytoplasmic esterase enzymes. This internal D-glutamate allows for production of metabolic fuctioning precursors such as α-ketoglutarate.